Screening for cystic fibrosis-related diabetes and prediabetes: Evaluating 1,5-anhydroglucitol, fruc

Researchers examined whether alternate glycemic markers—hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)—have utility as screening tests for cystic fibrosis (CF)-related diabetes (CFRD) and prediabetes (CFPD) in youth with CF as defined by the gold-standard oral glucose tolerance tests (OGTT) 2-hour glucose (2hG). Collection of youth 10 to 18 years with CF who had a 1,5AG, FA, GA, HbA1c, and 2-hour OGTT was done. They included 58 youth with CF (2hG < 140, n = 16; CFPD, n = 33; CFRD, n = 9; 41% male, mean ± SD age 14.2 ± 3.6 years, BMI z-score 0.0 ± 0.8, % predicted forced expiratory volume in 1 second 89.9 ± 15.1, % predicted forced vital capacity 103.2 ± 14.6). Findings revealed poor diagnostic accuracy of all alternate markers tested for identifying CFRD by 2hG.

Read the full article on Pediatric Diabetes

Featured Posts
Recent Posts
Archive
Search By Tags

Support Zahra's run for Palestine CF patients.

  • Facebook Clean
  • Twitter Clean
  • Instagram - Grey Circle
  • YouTube - Grey Circle
  • LinkedIn Clean