Developer Recode Therapeutics expects results by end of 2026 Written by Patricia Inácio, PhD A Phase 2a clinical trial testing RCT2100, Recode Therapeutics’ investigational inhaled mRNA therapy for cystic fibrosis (CF), is fully enrolled, with results expected by the end of the year, the company announced. The clinical updates were part of a broader company announcement focused on Recode’s CF programs, which also included new funding from the Cystic Fibrosis Foundation and a

Researchers will test gene-corrected airway cells and a biodegradable scaffold Written by Patricia Inácio, PhD The Cystic Fibrosis Foundation is funding a new research project that aims to develop a cell-based strategy for rebuilding damaged airway tissue in people with cystic fibrosis (CF). Do-Yeon Cho, MD, a professor in the Department of Otolaryngology–Head and Neck Surgery at the University of Alabama at Birmingham (UAB), received the Path to a Cure Pilot & Feasibility Aw

Still, individualized treatment approaches urged for patients Written by Marisa Horak, MS Use of Trikafta, an approved oral medication for cystic fibrosis (CF), can reduce airway inflammation — known to exacerbate symptoms — in people with the genetic disease, a new study demonstrates. However, after a year of treatment, CF patients on Trikafta still show differences in airway inflammation compared with what’s seen in people without CF, the researchers noted. The findings sug

Technology could pave way for faster, more precise, personalized treatment Written by Marisa Horak, MS Cutting-edge DNA sequencing technologies for microbial surveillance have the potential to revolutionize how lung infections in people with cystic fibrosis (CF) are diagnosed and managed, according to a new review study. However, researchers noted that there are still challenges that need to be overcome before these technologies can be adopted into widespread clinical tools.

Surgeons at Northwestern Memorial Hospital successfully transplanted a second set of lungs, a liver, and a kidney into a patient with cystic fibrosis and chronic organ rejection. RT’s Three Key Takeaways: Complex Lung Retransplantation: Surgeons successfully performed a second double-lung transplant alongside liver and kidney transplants for a patient with restrictive allograft syndrome. Machine Perfusion Technology: The use of advanced machine perfusion allowed the surgical

Study: Method tracks grip strength, body composition in patients on Trikafta Written by Andrea Lobo, PhD A new model based on body composition and hand grip strength may help clinicians identify children with cystic fibrosis (CF) at risk of rapid weight gain or weight loss after starting Trikafta (elexacaftor/tezacaftor/ivacaftor), a new study suggests. In 27 children treated with Trikafta, researchers found that weight responses varied widely, with some children experiencing

Izmir, Türkiye – June 7, 2026 – The Middle East Cystic Fibrosis Association (MECFA) is proud to announce that it has been awarded a Vertex Circle of Care Grant to launch the MENA CF Adulting & Transition Lab – Türkiye Pilot, a collaborative initiative designed to strengthen transition support for adolescents and young adults living with cystic fibrosis (CF). The project is being implemented in partnership with Marmara University Selim Çöremen Cystic Fibrosis Center, Türkiye's

Cystic fibrosis treatments are improving patients’ quality of life. Three physicians from University of Iowa Health Care share more about cystic fibrosis. By Sara Berg, MS News Editor Cystic fibrosis (CF) is a lifelong genetic condition that primarily affects the lungs and digestive system, making everyday tasks like breathing and eating more difficult than most people ever realize or experience. Caused by changes in a single gene, cystic fibrosis leads to thick, sticky mucu

I'm still learning to navigate a new set of health challenges Written by Jennifer Cogliano Five and a half years ago, I received the gift of a lifetime: a double-lung transplant that gave me back my breath and, in many ways, my life. After decades of fighting cystic fibrosis (CF), I finally felt free. And then reality set in. Nobody tells you that a transplant isn’t a finish line. It’s more like a beautiful, necessary, lifesaving detour that leads you onto a completely diffe

RESEARCHERS at University California, Los Angeles (UCLA) have developed a lipid nanoparticle (LNP)-based system capable of delivering the full cystic fibrosis transmembrane conductance regulator (CFTR) gene into human airway cells. The LNPs carry CRISPR/Cas9 components, guide RNAs, and a linear DNA template for homology-directed repair, allowing precise insertion of the complete CFTR gene without the use of viral vectors. This non-viral approach overcomes limitations associat